Jacobsen JPR, Oh A, Bangle R, et al. Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept. Neuropsychopharmacology. 2019;44(12):2082-2090.
This comprehensive study was designed to optimize translational fidelity, It reports that high-dose oral adjunctive 5-HTP slow-release in mice is safe and effective in amplifying brain serotonin neurotransmission beyond the SSRI effect, as assessed by behavioral, biochemical, and gene transcription measures.
Jacobsen JPR, Krystal AD, Krishnan KRR, et al. Adjunctive 5-hydroxytryptophan slow-release for treatment-resistant depression: clinical and preclinical rationale. Trends Pharmacol Sci. 2016;37(11):933-944.
This paper reviews the multipronged clinical data supporting that adjunctive 5-HTP SR could treat depression patients responding inadequately to first-line SSRI/SNRI antidepressants. That clinical data relates to earlier 5-HTP clinical research as well as clinical research with serotonergic antidepressants and compounds more broadly. Key supportive preclinical data is reviewed as well.
Jacobsen JP, Rudder ML, Roberts W, et al. SSRI augmentation by 5-hydroxytryptophan slow release: mouse pharmacodynamic proof of concept. Neuropsychopharmacology. 2016;41(9):2324-2334.
This study reports that 5-HTP slow-release synergizes with chronic SSRI in elevating extracellular serotonin in mice. It further demonstrates, assessing across a variety of physiological and behavioral measures, that slow-release delivery dramatically improves the safety and tolerability of 5-HTP administration.